Top 25 College Hoops Picks Against the Spread – Tuesday, January 21

Published 12:28 am Tuesday, January 21, 2025

There are 12 games featuring a ranked team on Tuesday’s college basketball schedule. Below, we provide against-the-spread picks for each contest.

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AP Top 25 Picks ATS Today

No. 4 Alabama Crimson Tide vs. Vanderbilt Commodores

Spread Prediction

  • Computer Prediction: Alabama 85, Vanderbilt 74
  • Projected Favorite: Alabama by 10.3 points
  • Pick ATS: Vanderbilt (+11.5)

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Bet on the Alabama-Vanderbilt spread—or any other NCAA men’s basketball matchup—with BetMGM!

Key Facts

  • Time: 7:00 PM ET
  • Location: Tuscaloosa, Alabama
  • Venue: Coleman Coliseum
  • TV Channel: SEC Network
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

No. 6 Tennessee Volunteers vs. No. 14 Mississippi State Bulldogs

Spread Prediction

  • Computer Prediction: Tennessee 76, Mississippi State 68
  • Projected Favorite: Tennessee by 7.5 points
  • Pick ATS: Tennessee (-7.5)

Bet on the Tennessee-Mississippi State spread—or any other NCAA men’s basketball matchup—with BetMGM!

Key Facts

  • Time: 7:00 PM ET
  • Location: Knoxville, Tennessee
  • Venue: Thompson-Boling Arena
  • TV Channel: ESPN2
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

No. 19 UConn Huskies vs. Butler Bulldogs

Spread Prediction

  • Computer Prediction: UConn 77, Butler 69
  • Projected Favorite: UConn by 7.6 points
  • Pick ATS: Butler (+12.5)

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Key Facts

  • Time: 7:00 PM ET
  • Location: Hartford, Connecticut
  • Venue: XL Center
  • TV Channel: Fox Sports 1
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

No. 11 Purdue Boilermakers vs. Ohio State Buckeyes

Spread Prediction

  • Computer Prediction: Purdue 78, Ohio State 70
  • Projected Favorite: Purdue by 7.3 points
  • Pick ATS: Ohio State (+10.5)

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Key Facts

  • Time: 7:30 PM ET
  • Location: West Lafayette, Indiana
  • Venue: Mackey Arena
  • TV Channel: Peacock
  • Live Stream: Peacock

No. 7 Houston Cougars vs. Utah Utes

Spread Prediction

  • Computer Prediction: Houston 79, Utah 61
  • Projected Favorite: Houston by 17.7 points
  • Pick ATS: Houston (-17.5)

Bet on the Houston-Utah spread—or any other NCAA men’s basketball matchup—with BetMGM!

Key Facts

  • Time: 8:00 PM ET
  • Location: Houston, Texas
  • Venue: Fertitta Center
  • TV Channel: ESPN+
  • Live Stream: Watch this game on ESPN+

No. 3 Iowa State Cyclones vs. UCF Knights

Spread Prediction

  • Computer Prediction: Iowa State 83, UCF 70
  • Projected Favorite: Iowa State by 12.6 points
  • Pick ATS: UCF (+15.5)

Bet on the Iowa State-UCF spread—or any other NCAA men’s basketball matchup—with BetMGM!

Key Facts

  • Time: 8:00 PM ET
  • Location: Ames, Iowa
  • Venue: James H. Hilton Coliseum
  • TV Channel: ESPN+
  • Live Stream: Watch this game on ESPN+

Seton Hall Pirates vs. No. 10 Marquette Golden Eagles

Spread Prediction

  • Computer Prediction: Marquette 77, Seton Hall 63
  • Projected Favorite: Marquette by 14.1 points
  • Pick ATS: Marquette (-12.5)

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Key Facts

  • Time: 8:00 PM ET
  • Location: Newark, New Jersey
  • Venue: Prudential Center
  • TV Channel: Peacock
  • Live Stream: Peacock

SMU Mustangs vs. No. 25 Louisville Cardinals

Spread Prediction

  • Computer Prediction: Louisville 77, SMU 76
  • Projected Favorite: Louisville by 0.1 points
  • Pick ATS: Louisville (+1.5)

Bet on the SMU-Louisville spread—or any other NCAA men’s basketball matchup—with BetMGM!

Key Facts

  • Time: 9:00 PM ET
  • Location: Dallas, Texas
  • Venue: Moody Coliseum
  • TV Channel: ACC Network
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

No. 23 West Virginia Mountaineers vs. Arizona State Sun Devils

Spread Prediction

  • Computer Prediction: West Virginia 74, Arizona State 68
  • Projected Favorite: West Virginia by 5.9 points
  • Pick ATS: Arizona State (+7.5)

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Key Facts

  • Time: 9:00 PM ET
  • Location: Morgantown, West Virginia
  • Venue: WVU Coliseum
  • TV Channel: CBS Sports Network
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Texas Longhorns vs. No. 22 Missouri Tigers

Spread Prediction

  • Computer Prediction: Missouri 76, Texas 75
  • Projected Favorite: Missouri by 0 points
  • Pick ATS: Missouri (+2.5)

Bet on the Texas-Missouri spread—or any other NCAA men’s basketball matchup—with BetMGM!

Key Facts

  • Time: 9:00 PM ET
  • Location: Austin, Texas
  • Venue: Moody Center
  • TV Channel: SEC Network
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

UCLA Bruins vs. No. 18 Wisconsin Badgers

Spread Prediction

  • Computer Prediction: UCLA 74, Wisconsin 73
  • Projected Favorite: UCLA by 0.2 points
  • Pick ATS: Wisconsin (+3.5)

Bet on the UCLA-Wisconsin spread—or any other NCAA men’s basketball matchup—with BetMGM!

Key Facts

  • Time: 9:30 PM ET
  • Location: Los Angeles, California
  • Venue: Pauley Pavilion
  • TV Channel: Peacock
  • Live Stream: Peacock

No. 15 Oregon Ducks vs. Washington Huskies

Spread Prediction

  • Computer Prediction: Oregon 78, Washington 68
  • Projected Favorite: Oregon by 9.3 points
  • Pick ATS: Washington (+12.5)

Bet on the Oregon-Washington spread—or any other NCAA men’s basketball matchup—with BetMGM!

Key Facts

  • Time: 11:00 PM ET
  • Location: Eugene, Oregon
  • Venue: Matthew Knight Arena
  • TV Channel: BTN
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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